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Prefrontal cortical regulation of brainwide circuit dynamics and reward-related behavior

2015; American Association for the Advancement of Science; Volume: 351; Issue: 6268 Linguagem: Inglês

10.1126/science.aac9698

1095-9203

Emily Ferenczi, Kelly A. Zalocusky, Conor Liston, Logan Grosenick, Melissa R. Warden, Debha N. Amatya, Kiefer Katovich, Hershel Mehta, Brian Patenaude, Charu Ramakrishnan, Paul Kalanithi, Amit Etkin, Brian Knutson, Gary H. Glover, Karl Deisseroth,

Receptor Mechanisms and Signaling

A way to modulate reward-seeking Which brain regions are causally involved in reward-related behavior? Ferenczi et al. combined focal, cell type-specific, optogenetic manipulations with brain imaging, behavioral testing, and in vivo electrophysiology (see the Perspective by Robbins). Stimulation of midbrain dopamine neurons increased activity in a brain region called the striatum and was correlated with reward-seeking across individual animals. However, elevated excitability of an area called the medial prefrontal cortex reduced both striatal responses to the stimulation of dopamine neurons and the behavioral drive to seek the stimulation of dopamine neurons. Finally, modulating the excitability of medial prefrontal cortex pyramidal neurons drove changes in neural circuit synchrony, as well as corresponding anhedonic behavior. These observations resemble imaging and clinical phenotypes observed in human depression, addiction, and schizophrenia. Science , this issue p. 10.1126/science.aac9698 ; see also p. 10.1126/science.aad9698