Produção Nacional
Revisado por pares
Global validation of the WSES Sepsis Severity Score for patients with complicated intra-abdominal infections: a prospective multicentre study (WISS Study)
2015; BioMed Central; Volume: 10; Issue: 1 Linguagem: Inglês
10.1186/s13017-015-0055-0
ISSN1749-7922
AutoresMassimo Sartelli, Fikri M. Abu‐Zidan, Fausto Catena, Ewen A. Griffiths, Salomone Di Saverio, Raúl Coimbra, Carlos A. Ordóñez, Ari Leppäniemi, Gustavo Pereira Fraga, Federico Coccolini, Ferdinando Agresta, Asrhaf Abbas, Saleh Abdel Kader, John Agboola, Adamu Amhed, A. J. Ajibade, Seçkin Akküçük, Bandar N Alharthi, Dimitrios Anyfantakis, Goran Augustin, Gian Luca Baiocchi, Miklosh Bala, Oussama Baraket, Savaş Bayrak, Giovanni Bellanova, Marcelo A. Beltrán, Roberto Bini, Matthew Boal, Andrey Vyacheslavovich Borodach, Konstantinos Bouliaris, Frédéric Branger, Daniele Brunelli, Marco Catani, Asri Che Jusoh, Alain Chichom‐Mefire, Gianfranco Cocorullo, Elif Çolak, David W. da Costa, S. Costa, Yunfeng Cui, Geanina Loredana Curca, Terry Curry, Koray Daş, Samir Delibegović, Zaza Demetrashvili, Isidoro Di Carlo, N. Drozdova, Tamer El Zalabany, Mushira Enani, Mário Paulo Faro, Mahir Gachabayov, Teresa Giménez Maurel, Georgios Gkiokas, Carlos Augusto Gomes, Ricardo Alessandro Teixeira Gonsaga, Gianluca Guercioni, Ali Güner, Sanjay Gupta, S. Pedraza Gutiérrez, M Hut'an, Orestis Ioannidis, Arda Işık, Yoshimitsu Izawa, Sumita Jain, Mantas Jokubauskas, Aleksandar Karamarković, Saila Kauhanen, Robin Kaushik, Jakub Kenig, Vladimir Khokha, Jae Il Kim, Victor Kong, Renol Koshy, Avidyl Krasniqi, Ashok Kshirsagar, Žygimantas Kuliešius, Konstantinos Lasithiotakis, Pedro Leão, Jae Gil Lee, Miguel León, Aintzane Lizarazu, Varut Lohsiriwat, Eudaldo López-Tomassetti Fernández, Eftychios Lostoridis, Raghuveer MN, Piotr Major, Athanasios Marinis, Daniele Marrelli, Aleix Martínez‐Pérez, Sanjay Marwah, Michael McFarlane, Renato Bessa Melo, Cristian Meşină, Nikolaos Michalopoulos, R Moldovanu, Ouadii Mouaqit, Akutu Munyika, Ionuţ Negoi, Ioannis Nikolopoulos, Gabriela Elisa Nita, Iyiade Olatunde Olaoye, Abdelkarim Omari, P Ossa, Zeynep Özkan, Ramakrishnapillai Padmakumar, Francesco Pata, Gerson Alves Pereira Júnior, Jorge Pereira, Tadeja Pintar, Konstantinos Pouggouras, Vinod Prabhu, Stefano Rausei, Miran Rems, Daniel Ríos‐Cruz, Boris Sakakushev, Maria Luisa Sánchez de Molina, Charampolos Seretis, Vishal G. Shelat, Romeo Lages Simões, Giovanni Sinibaldi, M Škrovina, Dmitry Smirnov, Charalampos Spyropoulos, Jaan Tepp, Tugan Tezcaner, Matti Tolonen, Myftar Torba, Jan Ulrych, Mustafa Yener Uzunoğlu, David van Dellen, Gabriëlle H. van Ramshorst, Giorgio Vasquez, Aurélien Venara, András Vereczkei, Nereo Vettoretto, N Vlad, Sanjay Kumar Yadav, Tonguç Utku Yılmaz, Kuo-Ching Yuan, Sanoop Koshy Zachariah, M Zida, Justas Žilinskas, Luca Ansaloni,
Tópico(s)Emergency and Acute Care Studies
ResumoTo validate a new practical Sepsis Severity Score for patients with complicated intra-abdominal infections (cIAIs) including the clinical conditions at the admission (severe sepsis/septic shock), the origin of the cIAIs, the delay in source control, the setting of acquisition and any risk factors such as age and immunosuppression. The WISS study (WSES cIAIs Score Study) is a multicenter observational study underwent in 132 medical institutions worldwide during a four-month study period (October 2014-February 2015). Four thousand five hundred thirty-three patients with a mean age of 51.2 years (range 18–99) were enrolled in the WISS study. Univariate analysis has shown that all factors that were previously included in the WSES Sepsis Severity Score were highly statistically significant between those who died and those who survived (p < 0.0001). The multivariate logistic regression model was highly significant (p < 0.0001, R2 = 0.54) and showed that all these factors were independent in predicting mortality of sepsis. Receiver Operator Curve has shown that the WSES Severity Sepsis Score had an excellent prediction for mortality. A score above 5.5 was the best predictor of mortality having a sensitivity of 89.2 %, a specificity of 83.5 % and a positive likelihood ratio of 5.4. WSES Sepsis Severity Score for patients with complicated Intra-abdominal infections can be used on global level. It has shown high sensitivity, specificity, and likelihood ratio that may help us in making clinical decisions.
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