Portal de Periódicos da CAPES

Metabolic connectivity mapping reveals effective connectivity in the resting human brain

2015; National Academy of Sciences; Volume: 113; Issue: 2 Linguagem: Inglês

10.1073/pnas.1513752113

1091-6490

Valentin Riedl, Lukas Utz, Gabriel Castrillón, Timo Grimmer, Josef P. Rauschecker, Markus Ploner, Karl Friston, Alexander Drzezga, Christian Sorg,

Neuroscience and Neuropharmacology Research

Significance Noninvasive brain imaging of humans identifies prominent networks related to sensory and cognitive functions in the resting state; however, the signaling hierarchy and directionality among these networks remain largely unknown. Integrating simultaneously recorded measures for network identification and regional energy metabolism, we propose metabolic connectivity mapping (MCM) as a novel measure to reveal signaling directionality in the human brain. Comparing simple “eyes closed” and “eyes open” conditions in healthy subjects, MCM revealed stable bidirectional signaling among visual cortices and top-down signaling from parietal control regions. Additional top-down signaling from a salience network occurs only during the eyes open condition. We propose MCM as a measure for investigating signaling directions among brain networks in healthy and diseased brains.