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BIBTEX RIS

Management considerations for childhood-onset systemic lupus erythematosus patients and implications on therapy

2015; Taylor & Francis; Volume: 12; Issue: 3 Linguagem: Inglês

10.1586/1744666x.2016.1123621

1744-8409

Clóvis A. Silva, Nádia Emi Aikawa, Rosa Maria Rodrigues Pereira, Lúcia Maria Arruda Campos,

Autoimmune and Inflammatory Disorders Research

Childhood-onset systemic lupus erythematosus (cSLE) is a chronic inflammatory and autoimmune disease that may involve various organs and systems. This narrative review focuses on the recent evidence relating to cSLE management. The general management considerations of cSLE patients require the use of validated classification criteria, disease and health-related quality of life tools evaluation, as well as assessments of lupus nephritis biomarkers and cSLE quality indicators. The drug treatment for cSLE patients includes general supportive care and immunosuppressive therapy. Important implications on cSLE therapy are also updated such as infection, vaccination, infertility, pregnancy, contraception, dyslipidemia, physical activity, cancer, bone health, drug pharmacokinetics, adherence, academic outcomes, transition to adult care and cumulative organ damage.