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Eosinophilic Myocarditis Presenting as ST-segment Elevation Myocardial Infarction Diagnosed with Cardiac Magnetic Resonance Imaging

2015; Elsevier BV; Volume: 129; Issue: 2 Linguagem: Inglês

10.1016/j.amjmed.2015.08.034

1555-7162

Grant Bailey, Krishna Upadhyaya, Judith Meadows, Brian Malm,

Cardiovascular Effects of Exercise

Acute ST-segment elevation myocardial infarction is a medical emergency requiring prompt recognition of the syndrome and initiation of reperfusion therapy. The usual pathophysiologic mechanism of transmural myocardial injury is acute thrombotic occlusion of an epicardial coronary artery. Other conditions can masquerade as ST-elevation myocardial infarction with different mechanisms of myocardial injury. We report a case of eosinophilic myocarditis manifesting as acute ST-segment elevation myocardial infarction in the setting of chronic idiopathic hypereosinophilia diagnosed using cardiac magnetic resonance imaging. A 60-year-old gentleman with a history of chronic obstructive pulmonary disease and hypertension was referred to the Emergency Department by his hematologist for further work-up of new-onset arthralgias, leukocytosis (23,000 cells/μL) with eosinophilia (41%), and elevated erythrocyte sedimentation rate (51 mm/h). He had been referred to a hematologist after a recent hospitalization with splenic infarcts, leukocytosis, and eosinophilia of unclear etiology. Further review of his records demonstrated eosinophilia as far back as 18 months before admission. During his previous admission, an extensive work-up including anticardiolipin antibody, beta-2 glycoprotein, antinuclear antibody, JAK2 mutation, FIP1L-PDGfRA, lupus anticoagulant, tryptase and bcr/abl, anti scl-70, antineutrophil cytoplasmic antibodies, anticyclic citrullinated peptide antibody, rheumatoid factor, flow cytometry, karyotyping, stool ova and parasites, and strongyloides, was negative. A bone marrow biopsy demonstrated significant eosinophilia, suggesting a hypereosinophilic state. He was admitted to our hospital for further evaluation and management. On day 1 of his hospitalization, he developed sudden-onset retrosternal chest pain while lying in bed. Electrocardiogram showed 3-mm ST-segment elevation in leads II, III, and AVF (Figure 1). Troponin I was elevated to 0.536 ng/mL. He was administered aspirin, clopidogrel, metoprolol, and atorvastatin, and started on an intravenous heparin infusion. A bedside transthoracic echocardiogram showed hypokinesis of the inferolateral and anterolateral segments, which were new compared with a previous echocardiogram (Figure 2). Urgent coronary angiography demonstrated mild nonobstructive coronary disease (Figure 3). He subsequently underwent cardiac magnetic resonance imaging using a Philips 3T scanner (Philips Healthcare, Andover, MA) with gadolinium contrast that was administered (0.2 mmol/kg) with images taken after a delay of 10 minutes. This demonstrated multiple noncontiguous focal areas of late gadolinium enhancement, including transmural and epicardial areas, with corresponding wall motion abnormalities, suggestive of infiltrative myocarditis (Figure 4).Figure 2Transthoracic echocardiogram apical 4-chamber views in diastole (A) and systole (B) showing hypokinesis of the mid-inferoseptum (arrows).View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure 3Coronary angiograms demonstrating normal left (A) and right (B) coronary arteries.View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure 4Cardiac magnetic resonance imaging 4-chamber (A) and short-axis (B) views demonstrating noncontiguous focal areas of late gadolinium enhancement in the mid septum and inferolateral walls.View Large Image Figure ViewerDownload Hi-res image Download (PPT) Hypereosinophilia is a syndrome whose hallmark feature is overproduction of eosinophils, defined as having an absolute eosinophil count of >1.5 × 109/L (1500/μL) on 2 separate occasions.1Chusid M.J. Dale D.C. West B.C. et al.The hypereosinophilic syndrome. Analysis of fourteen cases with review of the literature.Medicine (Baltimore). 1975; 54: 1-27Crossref PubMed Scopus (1196) Google Scholar This is often noted incidentally on routine blood work, and the cause is not immediately obvious. A hypereosinophilic syndrome is diagnosed when there is evidence of end-organ damage from eosinophilic tissue infiltration with resultant oxidative and enzymatic injury.2Weller P.F. Bubley G.J. The idiopathic hypereosinophilic syndrome.Blood. 1994; 83: 2759-2779PubMed Google Scholar, 3Tai P.C. Ackerman S.J. Spry C.J. et al.Deposits of eosinophil granule proteins in cardiac tissues of patients with eosinophilic endomyocardial disease.Lancet. 1987; 1: 643-647Abstract PubMed Scopus (244) Google Scholar Myocardial involvement is common, occurring in upwards of 60% of patients with hypereosinophilic syndrome, and is now a major cause of morbidity and mortality if not treated appropriately.4ten Oever J. Theunissen L.J. Tick L.W. Verbunt R.J. Cardiac involvement in hypereosinophilic syndrome.Neth J Med. 2011; 69: 240-243PubMed Google Scholar, 5Kleinfeldt T. Nienaber C.A. Kische S. et al.Cardiac manifestation of the hypereosinophilic syndrome: new insights.Clin Res Cardiol. 2010; 99: 419-427Crossref PubMed Scopus (66) Google Scholar, 6Al Ali A.M. Straatman L.P. Allard M.F. Ignaszewski A.P. Eosinophilic myocarditis: case series and review of literature.Can J Cardiol. 2006; 22: 1233-1237Abstract Full Text PDF PubMed Scopus (98) Google Scholar The association between eosinophilia and cardiac injury was first described by Löffler in 1936,7Löffler W. Schweiz Med Wochenschr. 1936; 18 ([German]): 817-820Google Scholar initially as fibroplastic endocarditis or Loeffler's endocarditis. He proposed that eosinophilic infiltration of the endocardium with resultant fibrosis was the mechanism of injury resulting in constrictive physiology and severe heart failure. Myocardial injury as a result of eosinophilic infiltration involves recruitment of eosinophils into the myocardial tissue with toxic degranulation.3Tai P.C. Ackerman S.J. Spry C.J. et al.Deposits of eosinophil granule proteins in cardiac tissues of patients with eosinophilic endomyocardial disease.Lancet. 1987; 1: 643-647Abstract PubMed Scopus (244) Google Scholar The current understanding of eosinophilic myocarditis describes a 3-stage process of myocardial injury.4ten Oever J. Theunissen L.J. Tick L.W. Verbunt R.J. Cardiac involvement in hypereosinophilic syndrome.Neth J Med. 2011; 69: 240-243PubMed Google Scholar, 5Kleinfeldt T. Nienaber C.A. Kische S. et al.Cardiac manifestation of the hypereosinophilic syndrome: new insights.Clin Res Cardiol. 2010; 99: 419-427Crossref PubMed Scopus (66) Google Scholar, 8Take M. Sekiguchi M. Hiroe M. et al.Clinical spectrum and endomyocardial biopsy findings in eosinophilic heart disease.Heart Vessels Suppl. 1985; 1: 243-249Crossref PubMed Scopus (23) Google Scholar, 9Fredy F. Iskandar W. Jih F. Cardiac involvement mimicking acute coronary syndrome in idiopathic hypereosinophilic syndrome.Acta Med Indones. 2013; 45: 302-305PubMed Google Scholar, 10Houman R. Sanchez-Ross M. Kaluski E. Klapholz M. Haider B. Gerula C. Acute eosinophilic myocarditis: diagnosis and treatment.Acute Cardiac Care. 2010; 12: 31-36Crossref PubMed Scopus (30) Google Scholar The first stage is the acute necrotic phase, which involves myocardial infiltration with eosinophils and toxic degranulation, resulting in myocardial injury. This stage is typically subclinical and patients are often asymptomatic. The second stage is the thrombotic phase, involving thrombus formation on the endocardial surface. Symptoms often first appear during this stage due to thromboembolic events. This was the case with our patient, who had initially presented with splenic infarcts. The final stage is a fibrotic phase, where scar replaces the injured myocardium, resulting in endomyocardial fibrosis, which may lead to a restrictive cardiomyopathy and congestive heart failure. Combinations of fibrosis and inflammation can be seen across a continuum in the latter 2 stages. There are few reported cases of ST-segment elevation myocardial infarction as the presenting feature of patients with eosinophilic myocarditis.11Amini R. Nielsen C. Eosinophilic myocarditis mimicking acute coronary syndrome secondary to idiopathic hypereosinophilic syndrome: a case report.J Med Case Rep. 2010; 4: 40Crossref PubMed Scopus (23) Google Scholar, 12Enriquez A. Castro P. Gabrielli L. et al.Acute necrotizing eosinophilic myocarditis presenting as ST-elevation myocardial infarction: a case report.Can J Cardiol. 2011; 27: 870.e1-870.e3Abstract Full Text Full Text PDF PubMed Scopus (9) Google Scholar, 13Takahasi N. Kondo K. Aoyagi J. Acute myocardial infarction associated with hypereosinophilic syndrome in a young man.Jpn Circ J. 1997; 61: 803-806Crossref PubMed Scopus (16) Google Scholar Endomyocardial biopsy (EMB) has historically been the gold standard for diagnosis of cardiac eosinophilic infiltration. However, due to the noncontiguous and patchy nature of eosinophilic infiltration, EMB may miss active areas of infiltration, resulting in a false negative and delaying diagnosis. Furthermore, EMB is an invasive procedure with the potential for serious complications, including cardiac perforation, conduction abnormalities, and pericardial effusion.14Holzmann M. Nicko A. Kühl U. et al.Complication rate of right ventricular endomyocardial biopsy via the femoral approach: a retrospective and prospective study analyzing 3048 diagnostic procedures over an 11-year period.Circulation. 2008; 118: 1722-1728Crossref PubMed Scopus (196) Google Scholar Cardiac magnetic resonance (CMR) imaging performed with gadolinium contrast enhancement can detect even early-stage cardiac involvement and can distinguish among the 3 stages.4ten Oever J. Theunissen L.J. Tick L.W. Verbunt R.J. Cardiac involvement in hypereosinophilic syndrome.Neth J Med. 2011; 69: 240-243PubMed Google Scholar, 15Debl K. Djavidani B. Buchner S. et al.Time course of eosinophilic myocarditis visualized by CMR.J Cardiovasc Magn Reson. 2008; 10: 20-21Crossref PubMed Scopus (21) Google Scholar, 16Kim Y. Chang S. Lee Y. Choi J. Hyeon Y. Early non-invasive diagnosis and treatment of acute eosinophlic myopericarditis by cardiac magnetic resonance.J Korean Med Sci. 2011; 26: 1522-1526Crossref PubMed Scopus (11) Google Scholar, 17Syed I. Martinez M. Feng D. Glockner J. Cardiac magnetic resonance imaging of eosinophilic endomyocardial disease.Int J Cardiol. 2008; 126: e50-e52Abstract Full Text Full Text PDF PubMed Scopus (63) Google Scholar During the first stage, CMR can detect necrosis and inflammation through sub-endocardial late gadolinium enhancement. In the second and third stages of eosinophilic myocarditis, CMR can visualize thrombi as well as areas of myocardial inflammation and fibrosis. Thrombi appear as hypointense areas overlying the endocardium, whereas inflammation and fibrosis are both hyper-enhanced lesions.4ten Oever J. Theunissen L.J. Tick L.W. Verbunt R.J. Cardiac involvement in hypereosinophilic syndrome.Neth J Med. 2011; 69: 240-243PubMed Google Scholar, 17Syed I. Martinez M. Feng D. Glockner J. Cardiac magnetic resonance imaging of eosinophilic endomyocardial disease.Int J Cardiol. 2008; 126: e50-e52Abstract Full Text Full Text PDF PubMed Scopus (63) Google Scholar