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Formation of Micronuclei and Inhibition of Topoisomerase II in the Comet Assay in Mammalian Cells with Altered DNA Methylation

1997; Springer Science+Business Media; Linguagem: Inglês

10.1007/978-3-642-60393-8_12

2197-6767

Helga Stopper, I Eckert, P. Wagener, Wolfgang A. Schulz,

RNA modifications and cancer

In mammalian DNA, 3%–5% of cytosine residues are present as 5-methylcytosine (Holiday and Grigg 1993). This methylation is involved in several epigenetic processes, including genomic imprinting and gene expression (Tilghman 1993). DNA hypomethylation is one of the possible causes and one of the consequences of mammalian neoplasia and also occurs in cultured cells after treatment with certain carcinogenic drugs (Spruck et al. 1993). Changes in DNA methylation can affect DNA conformation (Bird 1992).