Regulation of Serotonin Receptors and Responsiveness in the Brain
1988; Humana Press; Linguagem: Inglês
10.1007/978-1-4612-4560-5_11
AutoresAlan Frazer, Steve Offord, Irwin Lucki,
Tópico(s)Neuroscience and Neuropharmacology Research
ResumoThe advent of radioligand binding methodology in vitro has greatly facilitated the study and understanding of the properties and regulation of many types of receptor sites, including those for 5-hydroxytryptamine (5-HT; serotonin). Given the many important behavioral functions ascribed to 5-HT, it is not surprising that much of this type of work has focused on serotonin receptors in the central nervous system (CNS). It is this body of research that will be reviewed in this chapter. In reviewing this information, we were impressed with obvious differences in agonist-induced regulation of receptors for 5-HT in comparison with that found for receptors of other putative transmitter substances (e.g., dopamine [DA], norepinephrine [NE], acetylcholine [ACh]). Whereas in other transmitter systems there is reasonably good concordance between drug-induced alterations in receptor density and responses linked to the receptors, this is not a consistent observation for serotonergic systems. In particular, there is a disparity between the decrease in the number of receptors for 5-HT caused by many antidepressant drugs and the ability of these same drugs to enhance certain electrophysiological responses elicited by 5-HT. Issues of this nature will be emphasized in this chapter.KeywordsSerotonin ReceptorRepeated AdministrationDorsal Raphe NucleusSerotonergic NeuronNicotinic Cholinergic ReceptorThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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