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Alpha-Glucosidase Inhibitory Activities of Wrightia tinctoria Roxb and Schrebera swietenoides Roxb Bark Extract.

2011; Volume: 3; Issue: 1 Linguagem: Inglês

2321-5836

D Lakshman Kumar, K. N. V. Rao, Madhavi Bindu, Dushyant Kumar, David Banji,

Natural Antidiabetic Agents Studies

Alpha glucosidase inhibitory activities of Wrightia tinctoria Roxb and Schrebera swietenoides Roxb ethanol extracts were investigated individually. Wrightia tinctoria Roxb and Schrebera swietenoides Roxb bark extract showed in-vitro inhibitory activity of intestinal alpha glucosidase enzyme maltase. Analysis of data confirms that alpha glucosidase inhibition activity was the maximum at 1500mcg/ml of Wrightia tinctoria Roxb bark and 2000mcg/ml of Schrebera swietenoides Roxb bark. The purpose of study was to know whether Wrightia tinctoria Roxb bark and Schrebera swietenoides Roxb bark extract could reduce intestinal absorption of monosaccharides by inhibiting disaccharide hydrolysis. These results suggest that the Wrightia tinctoria Roxb bark extract and Schrebera swietenoides Roxb bark has little potent alpha glucosidase inhibitory activity individually and would be effective in suppression of elevation in blood glucose.