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Protein Arginine Methylation and Citrullination in Epigenetic Regulation

2015; American Chemical Society; Volume: 11; Issue: 3 Linguagem: Inglês

10.1021/acschembio.5b00942

1554-8937

Jakob Fuhrmann, Paul R. Thompson,

Peptidase Inhibition and Analysis

The post-translational modification of arginine residues represents a key mechanism for the epigenetic control of gene expression. Aberrant levels of histone arginine modifications have been linked to the development of several diseases including cancer. In recent years, great progress has been made in understanding the physiological role of individual arginine modifications and their effects on chromatin function. The present review aims to summarize the structural and functional aspects of histone arginine modifying enzymes and their impact on gene transcription. We will discuss the potential for targeting these proteins with small molecules in a variety of disease states.