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Ethnic-Specific Normative Reference Values for Echocardiographic LA and LV Size, LV Mass, and Systolic Function

2015; Elsevier BV; Volume: 8; Issue: 6 Linguagem: Inglês

10.1016/j.jcmg.2015.02.014

1936-878X

Katrina Poppe, R. Doughty, Julius M. Gardin, Richard Hobbs, John J.V. McMurray, Sherif F. Nagueh, Roxy Senior, Liza Thomas, Gillian Whalley, Erlend Aune, Alex Brown, Luigi P. Badano, Vicky A. Cameron, D.S. Chadha, Navtej Chahal, Kuo‐Liong Chien, Masao Daimon, Håvard Dalen, R. Detrano, Mehmet Akif Düzenli, Justin A. Ezekowitz, Giovanni de Simone, P Di Pasquale, S. Fukuda, P.S. Gill, Ehud Grossman, Richard Hobbs, H.-K. Kim, Tatiana Kuznetsova, Nelson Leung, Aleš Linhart, Theresa A. McDonagh, Michele McGrady, John J.V. McMurray, José Geraldo Mill, Rasmus Møgelvang, María Lorenza Muiesan, Arnold C.T. Ng, Dike Ojji, J. E. Otterstad, D.J. Petrovic, Katrina Poppe, Brian Prendergast, E. Rietzschel, Henrik Schirmer, Paulo Roberto Schvartzman, Roxy Senior, Iana Simova, Karen Sliwa, Simon Stewart, Iain Squire, Masaaki Takeuchi, Liza Thomas, Gillian Whalley, D G Altman, Rafael Perera, Katrina Poppe, C.M. Triggs, Howa Yeung, G Picon, Katrina Poppe, Gillian Whalley, Todd J. Anderson, Jason R.B. Dyck, Justin A. Ezekowitz, Julio A. Chirinos, Marc De Buyzere, Thierry Gillebert, E. Rietzschel, Patrick Segers, Caroline M. Van daele, R. Doughty, Katrina Poppe, Helen Walsh, Gillian Whalley, Raffaele Izzo, Nicola De Luca, Bruno Trimarco, Giovanni de Simone, D.S. Chadha, Kashish Goel, Artika Misra, Pau‐Chung Chen, Hsiang-Yu Lin, Ta‐Chen Su, R. Detrano, Vicky A. Cameron, Mark Richards, Richard W. Troughton, Rasmus Møgelvang, Jan Skov Jensen, P Di Pasquale, Salvatore Paterna, Mehmet Akif Düzenli, Richard Hobbs, Michael K. Davies, Russell Davis, Andrea Roalfe, Melanie Calvert, Michael K. Davies, Russell Davis, Nick Freemantle, P.S. Gill, Gregory Y.H. Lip, Tatiana Kuznetsova, Jan A. Staessen, Henry J. Dargie, Ian Ford, Theresa A. McDonagh, John J.V. McMurray, Ehud Grossman, Gavin Galasko, Avijit Lahiri, Roxy Senior, Alex Brown, M. Carrington, Henry Krum, Michele McGrady, Simon Stewart, C. Zeitz, Lori A. Blauwet, Karen Sliwa, Simon Stewart, Håvard Dalen, H.E. Hansen, Asbjørn Støylen, Anders Thorstensen, Masao Daimon, Hiroyuki Watanabe, J. Yoshikawa, S. Fukuda, H.-K. Kim, Nelson Leung, Aleš Linhart, Navtej Chahal, John C. Chambers, Jaspal S. Kooner, Roxy Senior, J.W.L. Davies, Ian Loke, Arnold C.T. Ng, Iain Squire, Erlend Aune, J. E. Otterstad, Dominic Y. Leung, Arnold C.T. Ng, Dike Ojji, Linda Arnold, Sean Coffey, Joanna d’Arcy, Christopher J. Hammond, C. Mabbett, Carmen Sílvia Passos Lima, Margaret Loudon, N Pinheiro, Brian Prendergast, Robert F. Reynolds, Luigi P. Badano, Denisa Muraru, Diletta Peluso, L. Dal Bianco, D.J. Petrovic, Jelena Petrović, Paulo Roberto Schvartzman, Flávio Danni Fuchs, Tzvetana Katova, Iana Simova, Kyoko Kaku, Masaaki Takeuchi, Anita Boyd, E.M. Chia, Liza Thomas, Henrik Schirmer, Lilian C. Angelo, Alexandre C. Pereira, José Eduardo Krieger, José Geraldo Mill, Sérgio Lamêgo Rodrigues, María Lorenza Muiesan, Anna Paini, Enrico Agabiti Rosei, Massimo Salvetti,

Cardiovascular Effects of Exercise

This study sought to derive age-, sex-, and ethnic-appropriate adult reference values for left atrial (LA) and left ventricular (LV) dimensions and volumes, LV mass, fractional shortening, and ejection fraction (EF) derived from geographically diverse population studies. The current recommended reference values for measurements from echocardiography may not be suitable to the diverse world population to which they are now applied. Population-based datasets of echocardiographic measurements from 22,404 adults without clinical cardiovascular or renal disease, hypertension, or diabetes were combined in an individual person data meta-analysis. Quantile regression was used to derive reference values at the 95th percentile (upper reference value [URV]) and fifth percentile (lower reference value [LRV]) of each measurement against age (treated as linear), separately within sex and ethnic groups. The URVs for left ventricular end-diastolic volume (LVEDV), LV end-systolic volume, and LV stroke volume (SV) were highest in Europeans and lowest in South Asians. Important sex and ethnic differences remained after indexation by body surface area or height for these measurements, as well as for the LRV for SV. LVEDV and SV decreased with increasing age for all groups. Importantly, the LRV for EF differed by ethnicity; there was a clear apparent difference between Europeans and Asians. The URVs for LV end-diastolic diameter and LV end-systolic diameter were higher for Europeans than those for East Asian, South Asian, and African people, particularly among men. Similarly, the URVs for LA diameter and volume were highest for Europeans. Sex- and/or ethnic-appropriate echocardiographic reference values are indicated for many measurements of LA and LV size, LV mass, and EF. Reference values for LV volumes and mass also differ across the age range.