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Structural and spectroscopic investigation on a new potentially bioactive di-hydrazone containing thiophene heterocyclic rings

2015; Elsevier BV; Volume: 1106; Linguagem: Inglês

10.1016/j.molstruc.2015.10.081

1872-8014

Vanessa de S. Nogueira, Maria Clara Ramalho Freitas, Wellington S. Cruz, Tatiana S. Ribeiro, Jackson A. L. C. Resende, Nicolás A. Rey,

Metal complexes synthesis and properties

Hydrazones and several substituted hydrazones are associated with a broad spectrum of biological activities, as well as compounds containing the thiophene ring. In this context, a novel di-hydrazone derived from 2-thiophenecarboxylic acid hydrazide was synthesized and completely characterized by elemental analysis, XRD, FT-IR, Raman and UV–Vis spectroscopies, thermogravimetry, 1H NMR, 1H–1H COSY and 1H–1H ROESY. A preliminary in silico pharmacological evaluation was also performed in order to assess the performance of the new compound regarding some molecular properties relevant for a drug's pharmacokinetics in the human body.