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New Alcamide and Anti-oxidant Activity of Pilosocereus gounellei A. Weber ex K. Schum. Bly. ex Rowl. (Cactaceae)

2015; Multidisciplinary Digital Publishing Institute; Volume: 21; Issue: 1 Linguagem: Inglês

10.3390/molecules21010011

1433-1373

Jéssica Da Silva Maciel, Otemberg Chaves, Severino Brito Filho, Yanna Carolina Ferreira Teles, Marianne Guedes Fernandes, Temilce Simões de Assis Cantalice, Pedro Dantas Fernandes, Alberício De Andrade, Leonardo P. Félix, Tânia Maria Sarmento Silva, Natália S. M. Ramos, Girliane Regina da Silva, Maria de Fátima Marinho de Souza,

Chemical synthesis and alkaloids

The Cactaceae family is composed by 124 genera and about 1438 species. Pilosocereus gounellei, popularly known in Brazil as xique-xique, is used in folk medicine to treat prostate inflammation, gastrointestinal and urinary diseases. The pioneering phytochemical study of P. gounellei was performed using column chromatography and HPLC, resulting in the isolation of 10 substances: pinostrobin (1), β-sitosterol (2), a mixture of sitosterol 3-O-β-d-glucopyranoside/stigmasterol 3-O-β-d-glucopyranoside (3a/3b), 132-hydroxyphaeophytin a (4), phaeophytin a (5), a mixture of β-sitosterol and stigmasterol (6a/6b), kaempferol (7), quercetin (8), 7′-ethoxy-trans-feruloyltyramine (mariannein, 9) and trans-feruloyl tyramine (10). Compound 9 is reported for the first time in the literature. The structural characterization of the compounds was performed by analyses of 1-D and 2-D NMR data. In addition, a phenolic and flavonol total content assay was carried out, and the anti-oxidant potential of P. gounellei was demonstrated.