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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Efeito ansiolítico da espermina microinjetada na substância cinzenta periaquedutal dorsal de ratos

2006; UNIVERSIDADE ESTADUAL DE MARINGÁ; Volume: 28; Issue: 1 Linguagem: Inglês

10.4025/actascihealthsci.v28i1.1113

ISSN

1807-8648

Autores

José Geraldo Pereira da Cruz, A.P. Carobrez,

Tópico(s)

Cannabis and Cannabinoid Research

Resumo

To investigate a possible effect of the spermine and its polyamins receptors in the dorsal periaqueductal grey (DPAG) in anxiety. Groups of rats received microinjections of spermine (2.5 nmol) into DPAG and were tested in the elevated plus-maze apparatus. Results indicated an overall significant increase in the percentage of entries and in the time spent in open arms. In another experiment the anxiolytic effect obtained after the microinjection of spermine (2.5 nmol) into DPAG was block by previous microinjection of polyamines antagonists, arcaine (4 nmol) or ifenprodil (5 nmol) into the same site. These results indicate that the spermine receptor interaction in the modulation of anxiety in rats exposed to the elevated plus-maze. Considering that polyamines are natural component of the brain, these results suggest that polyamine system within DPAG may play a role in aversion and anxiety

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