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Synthesis and characterization of a HAp-based biomarker with controlled drug release for breast cancer

2016; Elsevier BV; Volume: 61; Linguagem: Inglês

10.1016/j.msec.2016.01.015

1873-0191

Maykel González‐Torres, Ulises Merino, S. Vargas, Francisco Quintanilla, R. Rodrı́guez,

Nanoparticle-Based Drug Delivery

A biocompatible hybrid porous polymer-ceramic material was synthesized to be used as a biomarker in the treatment of breast cancer. This device was equipped with the capacity to release medicaments locally in a controlled manner. The biomaterial was Hydroxyapatite(HAp)-based and had a controlled pore size and pore volume fraction. It was implemented externally using a sharp end and a pair of barbed rings placed opposite each other to prevent relative movement once implanted. The biomarker was impregnated with cis-diamine dichloride platinum (II) [Cl2-Pt-(NH3)2]; the rate of release was obtained using inductively coupled plasma atomic emission spectroscopy (ICP-AES), and release occurred over the course of three months. Different release profiles were obtained as a function of the pore volume fraction. The biomaterial was characterized using scanning electron microscopy (SEM) and Raman spectroscopy.