Cross-talk among flesh-eating Aeromonas hydrophila strains in mixed infection leading to necrotizing fasciitis
2016; National Academy of Sciences; Volume: 113; Issue: 3 Linguagem: Inglês
10.1073/pnas.1523817113
ISSN1091-6490
AutoresDuraisamy Ponnusamy, Елена Козлова, Jian Sha, Tatiana E. Erova, Sasha R. Azar, Eric C. Fitts, Michelle L. Kirtley, Bethany L. Tiner, Jourdan A. Andersson, Christopher J. Grim, Richard Isom, Nur A. Hasan, Rita R. Colwell, Ashok K. Chopra,
Tópico(s)Infections and bacterial resistance
ResumoSignificance Necrotizing fasciitis (NF) is a rapidly progressing fatal skin and muscle tissue lesion. We studied a human case of NF and found that the infection was caused by multiple strains of A. hydrophila (NF1–NF4). The latter three strains constitute a clonal group, whereas NF1 is phylogenetically distinct. We tested these strains individually in a mouse intramuscular model of infection and observed NF1 to be less virulent than NF2. However, when NF1 and NF2 were mixed, NF1 exhibited more virulence and it decreased NF2 virulence. The cross-talk between NF1 and NF2 was due to the presence of ExoA toxin in NF2, ability of NF1 and NF2 to differentially modulate innate immune mechanism(s), and direct killing of NF2 by NF1.
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