Artigo Revisado por pares

Uptake and release of free fatty acids and other metabolites in the legs of exercising men.

1967; American Physiological Society; Volume: 23; Issue: 1 Linguagem: Inglês

10.1152/jappl.1967.23.1.90

ISSN

8750-7587

Autores

Richard J. Havel, Bengt Pernow, Norman L. Jones,

Tópico(s)

Cardiovascular and exercise physiology

Resumo

ArticleUptake and release of free fatty acids and other metabolites in the legs of exercising men.R J Havel, B Pernow, and N L JonesR J Havel, B Pernow, and N L JonesPublished Online:01 Jul 1967https://doi.org/10.1152/jappl.1967.23.1.90MoreSectionsPDF (1 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByA Brief History of Exercise Metabolism19 July 2022Exercise: Thermodynamic and Bioenergetic Principles19 July 2022Exercise-Regulated Skeletal Muscle Glucose Uptake19 July 2022The many actions of insulin in skeletal muscle, the paramount tissue determining glycemiaCell Metabolism, Vol. 33, No. 4Biochemical adaptations in white adipose tissue following aerobic exercise: from mitochondrial biogenesis to browning18 March 2020 | Biochemical Journal, Vol. 477, No. 6Nutrition from the Inside OutAnnual Review of Nutrition, Vol. 37, No. 1Role of reactive oxygen species in regulation of glucose transport in skeletal muscle during exercise24 February 2016 | The Journal of Physiology, Vol. 594, No. 11The Physiological Regulation of Skeletal Muscle Fatty Acid Supply and Oxidation During Moderate-Intensity Exercise9 November 2015 | Sports Medicine, Vol. 45, No. S1Exercise Metabolism: Historical PerspectiveCell Metabolism, Vol. 22, No. 1Fat Needs in Masters Athletes1 October 2014Fat Metabolism29 October 2013Exercise, GLUT4, and Skeletal Muscle Glucose UptakeErik A. Richter, and Mark Hargreaves1 July 2013 | Physiological Reviews, Vol. 93, No. 3Ramadan and Its Effect on Fuel Selection during Exercise and Following Exercise Training1 September 2011 | Asian Journal of Sports Medicine, Vol. 2, No. 3Central fatigue and neurotransmitters, can thermoregulation be manipulated?4 October 2010 | Scandinavian Journal of Medicine & Science in Sports, Vol. 20Fat as a fuel: emerging understanding of the adipose tissue-skeletal muscle axis26 March 2010 | Acta Physiologica, Vol. 199, No. 4Physical Activity in Diet-Induced Disease Causation and Prevention in Women and Men12 May 2010Triglyceride-Rich Lipoproteins and Plasma Lipid TransportArteriosclerosis, Thrombosis, and Vascular Biology, Vol. 30, No. 1Glycemic Index in Sport NutritionJournal of the American College of Nutrition, Vol. 28, No. sup4Role of GPR81 in lactate-mediated reduction of adipose lipolysisBiochemical and Biophysical Research Communications, Vol. 377, No. 3Do Sex or Race Differences Influence Strength Training Effects on Muscle or Fat?Medicine & Science in Sports & Exercise, Vol. 40, No. 4Evaluation of intramyocellular lipid breakdown during exercise by biochemical assay, NMR spectroscopy, and Oil Red O stainingK. De Bock, T. Dresselaers, B. Kiens, E. A. Richter, P. Van Hecke, and P. Hespel1 July 2007 | American Journal of Physiology-Endocrinology and Metabolism, Vol. 293, No. 1Intramyocellular Lipid Content in Human Skeletal Muscle*Obesity, Vol. 14, No. 3Skeletal Muscle Lipid Metabolism in Exercise and Insulin ResistanceBente Kiens1 January 2006 | Physiological Reviews, Vol. 86, No. 1Central FatigueSports Medicine, Vol. 36, No. 10Use of intramuscular triacylglycerol as a substrate source during exercise in humansLuc J. C. van Loon1 October 2004 | Journal of Applied Physiology, Vol. 97, No. 4Níveis de triglicerídeos intra e extracelulares em músculos humanos mediante ¹H-ERM: um estudo de casoRevista Brasileira de Medicina do Esporte, Vol. 10, No. 5Fat metabolism in exercise - with special reference to training and growth hormone administrationScandinavian Journal of Medicine and Science in Sports, Vol. 14, No. 2Insulin resistance and elevated triglyceride in muscle: more important for survival than 'thrifty' genes?3 February 2004 | The Journal of Physiology, Vol. 554, No. 3Glucose ingestion blunts hormone-sensitive lipase activity in contracting human skeletal muscleMatthew J. Watt, Peter Krustrup, Niels H. Secher, Bengt Saltin, Bente K. Pedersen, and Mark A. Febbraio1 January 2004 | American Journal of Physiology-Endocrinology and Metabolism, Vol. 286, No. 1Muscle Triglyceride and Glycogen in Endurance ExerciseSports Medicine, Vol. 34, No. 3Intramyocellular lipids form an important substrate source during moderate intensity exercise in endurance‐trained males in a fasted state1 December 2003 | The Journal of Physiology, Vol. 553, No. 2Influence of prolonged endurance cycling and recovery diet on intramuscular triglyceride content in trained malesLuc J. C. van Loon, Vera B. Schrauwen-Hinderling, René Koopman, Anton J. M. Wagenmakers, Matthijs K. C. Hesselink, Gert Schaart, M. Eline Kooi, and Wim H. M. Saris1 October 2003 | American Journal of Physiology-Endocrinology and Metabolism, Vol. 285, No. 4Skeletal muscle fat and carbohydrate metabolism during recovery from glycogen-depleting exercise in humansThe Journal of Physiology, Vol. 548, No. 3Routes of FA delivery to cardiac muscle: modulation of lipoprotein lipolysis alters uptake of TG-derived FAAyanna S. Augustus, Yuko Kako, Hiroaki Yagyu, and Ira J. Goldberg1 February 2003 | American Journal of Physiology-Endocrinology and Metabolism, Vol. 284, No. 2Intramuscular triacylglycerol utilization in human skeletal muscle during exercise: is there a controversy?Matthew J. Watt, George J. F. Heigenhauser, and Lawrence L. Spriet1 October 2002 | Journal of Applied Physiology, Vol. 93, No. 4Human Skeletal Muscle Fatty Acid and Glycerol Metabolism During Rest, Exercise and Recovery1 September 2002 | The Journal of Physiology, Vol. 543, No. 3The Effect of a 3-Month Low-Intensity Endurance Training Program on Fat Oxidation and Acetyl-CoA Carboxylase-2 ExpressionDiabetes, Vol. 51, No. 7Intramuscular triacylglycerol, glycogen and acetyl group metabolism during 4 h of moderate exercise in man1 June 2002 | The Journal of Physiology, Vol. 541, No. 3Effect of exercise training at different intensities on fat metabolism of obese menDorien P. C. Van Aggel-Leijssen, Wim H. M. Saris, Anton J. M. Wagenmakers, Joan M. Senden, and Marleen A. Van Baak1 March 2002 | Journal of Applied Physiology, Vol. 92, No. 3Gender differences in substrate utilization during submaximal exercise in endurance-trained subjectsCarsten Roepstorff, Charlotte H. Steffensen, Marianne Madsen, Bente Stallknecht, Inge-Lis Kanstrup, Erik A. Richter, and Bente Kiens1 February 2002 | American Journal of Physiology-Endocrinology and Metabolism, Vol. 282, No. 2High carbohydrate availability increases LCFA uptake and decreases LCFA oxidation in perfused muscleLorraine P. Turcotte, Jason R. Swenberger, and Alice J. Yee1 January 2002 | American Journal of Physiology-Endocrinology and Metabolism, Vol. 282, No. 1Reduced synthesis of NO causes marked alterations in myocardial substrate metabolism in conscious dogsFabio A. Recchia, Juan Carlos Osorio, Margaret P. Chandler, Xiaobin Xu, Ashish R. Panchal, Gary D. Lopaschuk, Thomas H. Hintze, and William C. Stanley1 January 2002 | American Journal of Physiology-Endocrinology and Metabolism, Vol. 282, No. 1Regulation of Muscle Glucose Uptake In Vivo1 January 2011Fatty acid kinetics and carbohydrate metabolism during electrical exercise in spinal cord-injured humansMichael Kjær, Flemming Dela, Fin Biering Sørensen, Niels H. Secher, Jens Bangsbo, Thomas Mohr, and Henrik Galbo1 November 2001 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 281, No. 5Lipids, Exercise, and Immunology14 December 2009Effect of some ante-mortem stressors on peri-mortem and post-mortem biochemical changes and tenderness in broiler breast muscle: a review23 September 2019 | World's Poultry Science Journal, Vol. 55, No. 4Skeletal muscle substrate metabolism during exercise: methodological considerations12 June 2007 | Proceedings of the Nutrition Society, Vol. 58, No. 4Correction factors for 13 C-labelled substrate oxidation at whole-body and muscle level12 June 2007 | Proceedings of the Nutrition Society, Vol. 58, No. 4ROLE OF FATS IN EXERCISEClinics in Sports Medicine, Vol. 18, No. 3Whole body glucose metabolismKenneth Zierler1 March 1999 | American Journal of Physiology-Endocrinology and Metabolism, Vol. 276, No. 3The influence of exercise on postprandial triacylglycerol metabolismAtherosclerosis, Vol. 141Lipid Metabolism During Exercise23 September 2012 | Sports Medicine, Vol. 26, No. 1Contraction-induced increase inVmaxof palmitate uptake and oxidation in perfused skeletal muscleLorraine P. Turcotte, Carsten Petry, Bente Kiens, and Erik A. Richter1 May 1998 | Journal of Applied Physiology, Vol. 84, No. 5Utilization of lipids during exercise in human subjects: metabolic and dietary constraints9 March 2007 | British Journal of Nutrition, Vol. 79, No. 2Influence of diet on the metabolic responses to exercise28 February 2007 | Proceedings of the Nutrition Society, Vol. 57, No. 01Exercise and postprandial lipid metabolism28 February 2007 | Proceedings of the Nutrition Society, Vol. 57, No. 01Exercise prescription for weight management28 February 2007 | Proceedings of the Nutrition Society, Vol. 57, No. 01Effect of endurance training on fatty acid metabolism during whole body exerciseMedicine &Science in Sports &Exercise, Vol. 29, No. 5Determinants of Gas Exchange and Acid–Base Balance During Exercise1 January 2011Glucose Utilization1 January 2011Lipid Metabolism in Muscle1 January 2011Effects of training duration on substrate turnover and oxidation during exerciseS. M. Phillips, H. J. Green, M. A. Tarnopolsky, G. J. F. Heigenhauser, R. E. Hill, and S. M. Grant1 November 1996 | Journal of Applied Physiology, Vol. 81, No. 5Triacylglycerol synthesis in the different skeletal muscle fiber sections of the ratL. Budohoski, J. Gorski, K. Nazar, H. Kaciuba-Uscilko, and R. L. Terjung1 September 1996 | American Journal of Physiology-Endocrinology and Metabolism, Vol. 271, No. 3Glucostatic control of intake and obesity11 October 2007 | Proceedings of the Nutrition Society, Vol. 55, No. 1BEffect of training and nutrition on the development of skeletal muscle1 February 2008 | Journal of Sports Sciences, Vol. 13, No. sup1Muscle fuel selection: effect of exercise and training28 February 2007 | Proceedings of the Nutrition Society, Vol. 54, No. 1Plasma Glucose Levels after Prolonged Strenuous Exercise Correlate Inversely with Glycemic Response to Food Consumed before ExerciseInternational Journal of Sport Nutrition, Vol. 4, No. 4Lipid Metabolite Responses to Diet and Training in Sled Dogs ,The Journal of Nutrition, Vol. 124Exercise endurance in rats: Roles of type I and II corticosteroid receptorsPhysiology & Behavior, Vol. 53, No. 6The Role of Plasma Non-esterified Fatty Acids During Exercise in Type 2 Diabetes MellitusDiabetic Medicine, Vol. 10, No. 2The impact of a short course of three lipid lowering drugs on fat oxidation during exercise in healthy volunteers.Postgraduate Medical Journal, Vol. 69, No. 809Free Fatty Acids in Exercising Arabian Horses Fed Two Common DietsThe Journal of Nutrition, Vol. 122, No. 1Effects of intravenous glutamate on substrate availability and utilization across the human heart and legMetabolism, Vol. 40, No. 4Heated hand vein blood is satisfactory for measurements during free fatty acid kinetic studiesMetabolism, Vol. 40, No. 4Glycogen and triglyceride utilization in relation to muscle metabolic characteristics in men performing heavy-resistance exerciseEuropean Journal of Applied Physiology and Occupational Physiology, Vol. 61, No. 1-2Weight set-point theory and the high-density lipoprotein concentrations of long-distance runnersMetabolism, Vol. 39, No. 5Lipid depletion and repletion in skeletal muscle following a marathonJournal of the Neurological Sciences, Vol. 94, No. 1-3Nutrition, Fluid Balance, and Physical PerformanceEtude par voie externe du métabolisme musculaire d'un acide gras marqué chez le sportifScience & Sports, Vol. 2, No. 2Fuel metabolism during exercise in normal and diabetic manDiabetes / Metabolism Reviews, Vol. 1, No. 4Lipid metabolism during exercise: Influence of trainingDiabetes / Metabolism Reviews, Vol. 2, No. 1-2Effect of beta-adrenergic blockers on the peripheral circulation in patients with peripheral vascular disease.Circulation, Vol. 72, No. 6Nutritional alterations at high altitude in manEuropean Journal of Applied Physiology and Occupational Physiology, Vol. 54, No. 5Nutrition and ExerciseMedical Clinics of North America, Vol. 69, No. 1Role of Fat Metabolism in ExerciseClinics in Sports Medicine, Vol. 3, No. 3Comparison of fetal and maternal hind limb metabolic quotients in sheepAmerican Journal of Obstetrics and Gynecology, Vol. 149, No. 4Exercise MetabolismThe metabolism of circulating non-esterified fatty acids by the whole animal, hind-limb muscle and uterus of pregnant ewes9 March 2007 | British Journal of Nutrition, Vol. 49, No. 1Blood metabolites during prolonged exercise in swimming and leg cyclingEuropean Journal of Applied Physiology and Occupational Physiology, Vol. 48, No. 1Hepatic gluconeogenesis and ketogenesis in hyperthyroidismLife Sciences, Vol. 28, No. 15-16LIPID METABOLISM IN LIVER AND SELECTED TISSUES AND IN THE WHOLE BODY OF RUMINANT ANIMALSThe Myogenic Response1 January 2011A comparative study of the lipid composition of white, intermediate, red and heart muscle in ratsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, Vol. 619, No. 1Lipoprotein lipase activity in adipose tissue and skeletal muscle of runners: Relation to serum lipoproteinsMetabolism, Vol. 27, No. 11Physical exercise and fuel homeostasis in diabetes mellitusDiabetologia, Vol. 14, No. 4INTRAMUSCULAR SUBSTRATE UTILIZATION DURING PROLONGED EXERCISEAnnals of the New York Academy of Sciences, Vol. 301, No. 1 The MarathonFREE FATTY ACID TURNOVER AND THE AVAILABILITY OF SUBSTRATES AS A LIMITING FACTOR IN PROLONGED EXERCISEAnnals of the New York Academy of Sciences, Vol. 301, No. 1 The MarathonSkeletal MuscleFatty acids as substrates for heart and skeletal muscle.Circulation Research, Vol. 38, No. 6Utilization of oxidizable substrates by the sheep hind limb: Effects of starvation and exerciseMetabolism, Vol. 25, No. 5REMOVAL OF EXOGENOUS TRIGLYCERIDES IN HUMAN FOREARM MUSCLE AND SUBCUTANEOUS TISSUE24 April 2009 | Acta Medica Scandinavica, Vol. 197, No. 1-6The Use of Fuels for Muscular WorkEffects of Cold Exposure and Feeding on Net Exchange of Plasma Free Fatty Acids and Glycerol across the Hind Leg of the Young OxResearch in Veterinary Science, Vol. 17, No. 2Effect of exercise and physical fitness on serum lipids and lipoproteinsAtherosclerosis, Vol. 20, No. 1Lactate inhibition of lipolysis in exercising manMetabolism, Vol. 23, No. 6The Effect of Glycerol on the Postexercise Lactate ClearanceActa Physiologica Scandinavica, Vol. 91, No. 1Heart rate and energy-yielding substrates in blood during long-lasting runningEuropean Journal of Applied Physiology and Occupational Physiology, Vol. 32, No. 4Effect of exercise on splanchnic exchange of free fatty acidsMetabolism, Vol. 22, No. 6ENERGY NEED, DELIVERY, AND UTILIZATION IN MUSCULAR EXERCISEEffect of Training on Esterified Fatty Acids and Carnitine in Muscle and on Lipolysis in Adipose Tissue in VitroActa Physiologica Scandinavica, Vol. 86, No. 2Plasma Glucagon Levels in Exercising ManNew England Journal of Medicine, Vol. 287, No. 4Effects of Catecholamines on MetabolismCarbohydrate and fat metabolism in contracting canine skeletal musclePfl�gers Archiv European Journal of Physiology, Vol. 331, No. 1Human Forearm Muscle Metabolism during Exercise VII. FFA Uptake and Oxidation at Different Work Intensities13 May 2010 | Scandinavian Journal of Clinical and Laboratory Investigation, Vol. 30, No. 4Rapid intracoronary radiopalmitate injection and myocardial fatty acid oxidationMetabolism, Vol. 20, No. 7MUSCULAR METABOLISM AND PHYSICAL EXERCISEActa Paediatrica, Vol. 60, No. s217The Liver as an Energy Source in Man During ExerciseMetabolism of Free Fatty Acids and Ketone Bodies in Skeletal MuscleGlucose Metabolism During Exercise in ManInfluence of Intensity and Duration of Exercise on Supply and Use of FuelsMetabolism of Free Fatty Acids During Exercise in Patients with Occlusive Arterial Disease of the LegCarbohydrate HomeostasisNew England Journal of Medicine, Vol. 283, No. 5Freie Fetts�uren, Glycerin und Triglyceride im arteriellen und femoralven�sen Blut vor und nach einem vierw�chigen k�rperlichen TrainingPfl�gers Archiv European Journal of Physiology, Vol. 316, No. 2Human Forearm Muscle Metabolism During Exercise: IV. Glucose Uptake at Different Work Intensities8 July 2009 | Scandinavian Journal of Clinical and Laboratory Investigation, Vol. 25, No. 2Human Forearm Muscle Metabolism during Exercise: V. Quantitative Aspects of Glucose Uptake and Lactate Production during Prolonged Exercise8 July 2009 | Scandinavian Journal of Clinical and Laboratory Investigation, Vol. 26, No. 1Effect of diet on body composition changes after experimental injury in ratsMetabolism, Vol. 18, No. 6O2 consumption and metabolite balance in the dog gastrocnemius at rest and during exercisePflügers Archiv, Vol. 309, No. 1Effect of 5-Methylpyrazole-3-Carboxylic Acid (MPCA) on Fat Mobilization, Ketogenesis and Glucose Metabolism during Exercise in ManOn muscle strength and the threshold of anaerobic workInternationale Zeitschrift f�r Angewandte Physiologie Einschlie�lich Arbeitsphysiologie, Vol. 27, No. 4Free fatty acid concentrations in normal and diseased human muscle and in blood sera from patients with neuro-muscular diseaseClinica Chimica Acta, Vol. 22, No. 2Human Forearm Muscle Metabolism during Exercise II Uptake, release and oxidation of individual FFA and glycerol8 July 2009 | Scandinavian Journal of Clinical and Laboratory Investigation, Vol. 21, No. 3Exercise testingBritish Journal of Diseases of the Chest, Vol. 61, No. 4 More from this issue > Volume 23Issue 1July 1967Pages 90-9 https://doi.org/10.1152/jappl.1967.23.1.90PubMed6028167History Published online 1 July 1967 Published in print 1 July 1967 Metrics

Referência(s)