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Leucine-rich repeat kinase 2 is a regulator of B cell function, affecting homeostasis, BCR signaling, IgA production, and TI antigen responses

2016; Elsevier BV; Volume: 292; Linguagem: Inglês

10.1016/j.jneuroim.2016.01.005

1872-8421

Makoto Kubo, Ryuichi Nagashima, Etsuro Ohta, Tatsunori Maekawa, Yumiko Isobe, Mitsue Kurihara, Koji Eshima, Kazuya Iwabuchi, Toshikuni Sasaoka, Sadahiro Azuma, Heather L. Melrose, Matthew J. Farrer, Fumiya Obata,

Signaling Pathways in Disease

LRRK2 is the causal molecule of autosomal dominant familial Parkinson's disease. B2 cells express a much higher LRRK2 mRNA level than B1 cells. To reveal the function of LRRK2 in B cells, we analyzed B cell functions in LRRK2-knockout (LRRK2−/−) mice. LRRK2−/− mice had significantly higher counts of peritoneal B1 cells than wild-type mice. After BCR stimulation, phosphor-Erk1/2 of splenic B2 cells was enhanced to a higher degree in LRRK2−/− mice. LRRK2−/− mice had a significantly higher serum IgA level, and TNP–Ficoll immunization increased the titer of serum anti-TNP IgM antibody. LRRK2 may play important roles in B cells.