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Circadian Rhythms and Depression: Clinical and Experimental Models

1997; Springer Science+Business Media; Linguagem: Inglês

10.1007/978-3-662-09355-9_17

1865-0325

Alan M. Rosenwasser, Anna Wirz‐Justice,

Sleep and Wakefulness Research

In this chapter we review clinical and experimental evidence linking biological rhythms and affective state, and explore possible mechanisms underlying these relationships. Alterations in circadian rhythmicity have been observed in association with mood disorders (Anderson and Wirz-Justice 1991; Wirz-Justice 1995) as well as in putative animal models of depression and/or altered affective state (Rosenwasser 1992). However, much of the evidence for covariation of chronobiological and affective parameters is correlative, and the causal bases for such observations have not been fully elucidated.