Successful Treatment with Intravenous Cyclophosphamide for Refractory Adult-Onset Still’s Disease
2015; Hindawi Publishing Corporation; Volume: 2015; Linguagem: Inglês
10.1155/2015/163952
ISSN2090-6889
AutoresYoshika Tsuji, Nozomi Iwanaga, Anna Adachi, Kinuyo Tsunozaki, Yasumori Izumi, Yuji Moriwaki, Kazuhiro Kurohama, Masahiro Ito, Atsushi Kawakami, Kiyoshi Migita,
Tópico(s)Family and Disability Support Research
ResumoWe report a 64-year-old female case of intractable adult-onset Still's disease (AOSD). Initial high-dose steroid therapy combined with cyclosporin A was ineffective against macrophage-activation syndrome (MAS), which was accompanied by the systemic type of AOSD. Treatment for MAS with intravenous cyclophosphamide resulted in remission of AOSD and a reduction in the high doses of steroids. Efficacy of biologics against MAS in AOSD is unclear. Cyclophosphamide, a conventional cytotoxic agent, should be considered as one of the therapeutic options for refractory types of AOSD with MAS.
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