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Differential inhibition of ketogenesis by malonyl-CoA in mitochondria from fed and starved rats

1980; Portland Press; Volume: 192; Issue: 3 Linguagem: Inglês

10.1042/bj1920955

1470-8728

G A Cook, David A. Otto, Neal W. Cornell,

Mitochondrial Function and Pathology

Rates of ketogenesis in mitochondria from fed or starved rats were identical at optimal substrate concentrations, but responded differently to inhibition by malonyl-CoA. Kinetic data suggest that the K1 for malonyl-CoA is greater in the starved animal. These results indicate that, for the regulation of ketogenesis in the starved state, the lower sensitivity of carnitine palmitoyltransferase to inhibition by malonyl-CoA may be more important than the concentration of malonyl-CoA.