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Genomic landscape of intracranial meningiomas

2016; American Association of Neurological Surgeons; Volume: 125; Issue: 3 Linguagem: Inglês

10.3171/2015.6.jns15591

1933-0693

Wenya Linda Bi, Malak Abedalthagafi, Peleg Horowitz, Pankaj K. Agarwalla, Yu Mei, Ayal A. Aizer, Ryan Brewster, Gavin P. Dunn, Ossama Al‐Mefty, Brian M. Alexander, Sandro Santagata, Rameen Beroukhim, Ian F. Dunn,

Glioma Diagnosis and Treatment

Meningiomas are the most common primary intracranial neoplasms in adults. Current histopathological grading schemes do not consistently predict their natural history. Classic cytogenetic studies have disclosed a progressive course of chromosomal aberrations, especially in high-grade meningiomas. Furthermore, the recent application of unbiased next-generation sequencing approaches has implicated several novel genes whose mutations underlie a substantial percentage of meningiomas. These insights may serve to craft a molecular taxonomy for meningiomas and highlight putative therapeutic targets in a new era of rational biology-informed precision medicine.