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Immune defence against Candida fungal infections

2015; Nature Portfolio; Volume: 15; Issue: 10 Linguagem: Inglês

10.1038/nri3897

1474-1741

Mihai G. Netea, Leo A. B. Joosten, J.W.M. van der Meer, Bart Jan Kullberg, Frank L. van de Veerdonk,

Gut microbiota and health

This Review describes the host immune response toCandida fungal infections. The authors detail the innate and adaptive immune mechanisms, as well as the non-immune mechanisms, that are involved in the antifungal response. They also discuss emerging evidence suggesting that both innate and adaptive immune cells contribute to immune memory against Candidaspecies. The immune response to Candida species is shaped by the commensal character of the fungus. There is a crucial role for discerning between colonization and invasion at mucosal surfaces, with the antifungal host defence mechanisms used during mucosal or systemic infection with Candida species differing substantially. Here, we describe how innate sensing of fungi by pattern recognition receptors and the interplay of immune cells (both myeloid and lymphoid) with non-immune cells, including platelets and epithelial cells, shapes host immunity to Candida species. Furthermore, we discuss emerging data suggesting that both the innate and adaptive immune systems display memory characteristics after encountering Candida species.