Studies on the Structure and Function of Interstitial Cell-Stimulating Hormone
1973; Elsevier BV; Linguagem: Inglês
10.1016/b978-0-12-571129-6.50019-1
AutoresHarold Papkoff, M.R. Sairam, Susan Walker Farmer, Choh Hao Li,
Tópico(s)Sperm and Testicular Function
ResumoThis chapter presents studies on the structure and function of interstitial cell-stimulating hormone (ICSH). It also describes the studies on the structure of human ICSH that have led to the elucidation of the amino acid sequence of the human ICSH-α subunit. Human ICSH and ovine follicle stimulating hormone (FSH) are known to contain sialic acid. When these hormones are treated with neuraminidase to release the sialic acid, no effect is observed with regard to their lipolytic activity. The chapter also discusses in vitro stimulation of lactic acid in prepubertal rat ovaries by gonadotropins and their subunits. A number of reports have appeared in the literature that demonstrate that gonadotropins are active in stimulating lactic acid production in prepubertal rat ovaries both in vivo and in vitro.
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