TNF and ROS Crosstalk in Inflammation
2016; Elsevier BV; Volume: 26; Issue: 4 Linguagem: Inglês
10.1016/j.tcb.2015.12.002
ISSN1879-3088
AutoresHeiko Blaser, Catherine Dostert, Tak W. Mak, Dirk Brenner,
Tópico(s)Cytokine Signaling Pathways and Interactions
ResumoTumor necrosis factor (TNF) is tremendously important for mammalian immunity and cellular homeostasis. The role of TNF as a master regulator in balancing cell survival, apoptosis and necroptosis has been extensively studied in various cell types and tissues. Although these findings have revealed much about the direct impact of TNF on the regulation of NF-κB and JNK, there is now rising interest in understanding the emerging function of TNF as a regulator of the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS). In this review we summarize work aimed at defining the role of TNF in the control of ROS/RNS signaling that influences innate immune cells under both physiological and inflammatory conditions.
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