Portal de Periódicos da CAPES

Amide α,β-Dehydrogenation Using Allyl-Palladium Catalysis and a Hindered Monodentate Anilide

2016; American Chemical Society; Volume: 138; Issue: 4 Linguagem: Inglês

10.1021/jacs.5b12924

1943-2984

Yifeng Chen, Aneta Turlik, Timothy R. Newhouse,

Chemical Synthesis and Analysis

A practical and direct method for the α,β-dehydrogenation of amides is reported using allyl-palladium catalysis. Critical to the success of this process was the synthesis and application of a novel lithium N-cyclohexyl anilide (LiCyan). The reaction conditions tolerate a wide variety of substrates, including those with acidic heteroatom nucleophiles.