A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle
2016; American Association for the Advancement of Science; Volume: 351; Issue: 6270 Linguagem: Inglês
10.1126/science.aad4076
ISSN1095-9203
AutoresBenjamin R. Nelson, Catherine A. Makarewich, Douglas M. Anderson, Benjamin R. Winders, Constantine D. Troupes, Fenfen Wu, Austin L. Reese, John McAnally, Xiongwen Chen, Ege T. Kavalali, Stephen C. Cannon, Steven R. Houser, Rhonda Bassel‐Duby, Eric N. Olson,
Tópico(s)RNA Research and Splicing
ResumoAnother micropeptide flexes its muscle Genome annotation is a complex but imperfect art. Attesting to its limitations is the growing evidence that certain transcripts annotated as long noncoding RNAs (lncRNAs) in fact code for small peptides with biologically important functions. One such lncRNA-derived micropeptide in mammals is myoregulin, which reduces muscle performance by inhibiting the activity of a key calcium pump. Nelson et al. describe the opposite activity in a second lncRNA-derived micropeptide in mammalian muscle, called DWORF (see the Perspective by Payre and Desplan). This peptide enhances muscle performance by activating the same calcium pump. DWORF may prove to be useful in improving the cardiac muscle function of mammals with heart disease. Science , this issue p. 271 ; see also p. 226
Referência(s)