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Xanthine dehydrogenase is transported to the Drosophila eye.

1989; Oxford University Press; Volume: 123; Issue: 3 Linguagem: Inglês

10.1093/genetics/123.3.503

1943-2631

Andrew G. Reaume, Stephen H. Clark, Arthur Chovnick,

Biochemical and Molecular Research

Abstract The rosy (ry) locus in Drosophila melanogaster codes for the enzyme xanthine dehydrogenase. Mutants that have no enzyme activity are characterized by a brownish eye color phenotype reflecting a deficiency in the red eye pigment. This report demonstrates that enzyme which is synthesized in some tissue other than the eye is transported and sequestered at the eye. Previous studies find that no leader sequence is associated with this molecule but a peroxisomal targeting sequence has been noted, and the enzyme has been localized to peroxisomes. This represents a rare example of an enzyme involved in intermediary metabolism being transported from one tissue to another and may also be the first example of a peroxisomal protein being secreted from a cell.