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BIBTEX RIS

Effects of swimming training on the femoral neck strength in growing rats with untreated streptozotocin-induced diabetes : original research

2014; Springer Nature; Volume: 15; Issue: 4 Linguagem: Inglês

ISSN

1528-3356

Autores

Da Silva, Ana Karina, Del Carlo, Ricardo Magrani Junqueira, Pinto da Matta, Sergio Luis, Louzada, Mario Jefferson Quirino, Rodrigues, Aurora Correa, Márcia Serra Ferreira, Drummond, Lucas Rios, de Castro, Cynthia Aparecida, Silva, Carlos Henrique Osorio, Natali, Antonio Blazquez José,

Tópico(s)

Diet and metabolism studies

Resumo

Background : While type 1 diabetes mellitus (T1DM) increases bone fragility physical exercise improves bone quality and strength. Research question : To test whether swimming training attenuates the deterioration of femoral neck structural and mechanical properties in growing rats with untreated streptozotocin (STZ)-induced T1DM. Type of study : Randomised controlled study. Methods : Male Wistar rats (4-weeks-old; initial body weight: 80-90 g) were divided into 4 groups of 10 animals: diabetes sedentary (DS; 60 mg/kg of STZ, single i.p.); diabetes exercised (DE; 60 mg/kg of STZ, single i.p.); control sedentary (CS, same single dose of vehicle); and control exercised (CE, same single dose of vehicle). Six weeks later animals from DE and CE groups underwent a low-intensity swimming training (5 sessions/wk, 90 min/session, load: 4% of body weight) for 8 weeks. The femoral neck mechanical properties were measured. Bone mineral density (BMD) and mineral content (BMC), as well as the femoral neck bone volume (BV/TV) and collagen content were assessed. Results : Rats with T1DM exhibited reduced body weight, femoral weight and length, BMC and BMD, femoral neck collagen content, BV/TV, trabecular thickness, maximum load, stiffness and tenacity, and increased trabecular spacing compared to controls. Swimming training increased femoral BMC and BMD, femoral neck collagen content, BV/TV, trabecular thickness, stiffness and yield point energy, and reduced trabecular spacing in control animals, but not in T1DM animals. Conclusion : Low-intensity swimming training seems to be ineffective in attenuating the deterioration of the femoral neck structural and mechanical properties in growing rats with untreated STZ-induced T1DM.

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