Cyclosporine: Chemistry, Structure-Activity Relationships and Mode of Action
1986; Springer Nature; Linguagem: Inglês
10.1007/978-3-642-70998-2_5
ISSN0177-8757
AutoresRoland M. Wenger, Trevor Payne, Max H. Schreier,
Tópico(s)Biochemical and Molecular Research
ResumoCyclosporine is a cyclic peptide with a selective immunosuppressive action. One of its 11 amino acids is a novel amino acid, (4R)-4-((E)-2-butenyl-4,N-dimethyl-L-threonine, the preparation of which allowed the synthesis of cyclosporine and specifically modified analogues. Structure-activity relationships emerging from the study of modified cyclosporins suggest that a large portion of the cyclosporine molecule is involved in interactions with its lymphocyte receptor and that this includes amino acids 1, 2, 3 and 11.
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