Portal de Periódicos da CAPES

Positron Emission Tomography (PET) utilizing Pittsburgh compound B (PIB) detects amyloid heart deposits in hereditary transthyretin amyloidosis (ATTR).

2015; BioMed Central; Volume: 10; Issue: S1 Linguagem: Inglês

10.1186/1750-1172-10-s1-o15

1750-1172

Björn Pilebro, Per Lindqvist, Sandra Gustafsson, Per Westermark, Torbjörn Sundström, Gunnar Antoni, Ole B. Suhr, Jens Sörensen,

Parathyroid Disorders and Treatments

Background DPD scintigraphy has been advocated for imaging cardiac amyloid in ATTR amyloidosis. PET utilizing 11C-Pittsburgh compound B (PIB) is the gold standard for imaging brain amyloid in Alzheimer’s disease. PIB was recently shown to identify cardiac amyloidosis in both AL and ATTR amyloidosis. In the ATTR population, two types of amyloid fibrils exist, one containing fragmented and full-length TTR (type A) and the other only full-length TTR (type B). The aim of this study was to further evaluate PIB-PET in patients with hereditary ATTR amyloidosis.