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Solubility of Paracetamol in Binary and Ternary Mixtures of Water + Acetone + Toluene

2000; American Chemical Society; Volume: 45; Issue: 3 Linguagem: Inglês

10.1021/je990272l

1520-5134

Roger A. Granberg, Åke C. Rasmuson,

Crystallization and Solubility Studies

The solubility of paracetamol (4-hydroxyacetanilide) in binary mixtures of acetone + water and acetone + toluene and in ternary mixtures of water + acetone + toluene is reported. The temperature range is −5 to +30 °C. In acetone + water the solubility increases to a maximum at approximately 25 mass % water before decreasing to a much lower value in pure water as compared to pure acetone. In acetone + toluene the solubility decreases monotonically with increasing toluene concentration. The water content has a strong influence also in ternary mixtures. Activity coefficients in the saturated solutions are estimated.