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THE RELATION OF WHOLE-BODY I 131 UPTAKE TO THYROID ACTIVITY IN THE DEVELOPING DOGFISH, SCYLIORHINUS CANICULA (L.)

1963; Marine Biological Laboratory (MBL); Volume: 124; Issue: 2 Linguagem: Inglês

10.2307/1539493

1939-8697

MARIE THERESE DIMOND,

Environmental Toxicology and Ecotoxicology

1. Embryos of Scyliorhinus canicula, removed from their cases and kept at either room temperature or 8° C., were treated with 0.05% thiourea or perchlorate, or they were untreated, for 11, 13, or 21 days previous to addition of I131 to their medium. After two days of exposure to I131 and a day of washing, whole-body counts were made. The thyroid glands were removed within four days and prepared for autoradiography.2. At 8° C., although the film indicated the presence of a slight amount of bound iodine in the controls, there was no marked difference in whole-body count in the three groups.3. At room temperature, the controls had very high counts and well-blackened autoradiograms, whereas the two experimental groups had low counts and no sign of organic iodine.4. Only the experimentals which were exposed to the goitrogens for 28 days showed histological responses, such as enlarged follicles and very numerous mitotic figures.5. Growth was inhibited at the low temperature, but apparently unaffected by either of the goitrogens at either temperature.