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Update on psoriasis immunopathogenesis and targeted immunotherapy

2015; Springer Science+Business Media; Volume: 38; Issue: 1 Linguagem: Inglês

10.1007/s00281-015-0539-8

1863-2300

Satveer K. Mahil, Francesca Capon, Juliet N. Barker,

Cytokine Signaling Pathways and Interactions

Over recent years, significant progress has been made in characterisation of the underlying pathogenic mechanisms in psoriasis, a common cutaneous disease that is associated with major systemic co-morbidity and reduced life expectancy. Basic science discoveries have informed the design of novel therapeutic approaches, many of which are now under evaluation in late-stage clinical trials. Here we describe the complex interplay between immune cell types and cytokine networks that acts within self-perpetuating feedback loops to drive cutaneous inflammation in psoriasis. Genetic studies have been pivotal in the construction of the disease model and more recently have uncovered a distinct aetiology for rare, pustular variants of psoriasis. The translation of mechanistic insights into potential advancements in clinical care will also be described, including several treatments that target the interleukin-23 (IL-23)/T17 immune axis.