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Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons

2016; Elsevier BV; Volume: 5; Issue: 3 Linguagem: Inglês

10.1016/j.molmet.2016.01.005

2212-8778

Luke K. Burke, Barbora Doslikova, Giuseppe D’Agostino, Megan Greenwald-Yarnell, Teodora Georgescu, Raffaella Chianese, Pablo B. Martínez de Morentin, Emmanuel Ogunnowo-Bada, Céline Cansell, Lourdes Valencia-Torres, Alastair S. Garfield, John Apergis‐Schoute, Daniel D. Lam, John R. Speakman, Marcelo Rubinstein, Malcolm J. Low, Justin J. Rochford, Martin G. Myers, Mark L. Evans, Lora K. Heisler,

Adipokines, Inflammation, and Metabolic Diseases

Obesity is one of the primary healthcare challenges of the 21st century. Signals relaying information regarding energy needs are integrated within the brain to influence body weight. Central among these integration nodes are the brain pro-opiomelanocortin (POMC) peptides, perturbations of which disrupt energy balance and promote severe obesity. However, POMC neurons are neurochemically diverse and the crucial source of POMC peptides that regulate energy homeostasis and body weight remains to be fully clarified.