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Formation of Oxalate in Pyridoxine or Thiamin Deficient Rats during Intravenous Xylitol Infusions

1977; Elsevier BV; Volume: 107; Issue: 3 Linguagem: Inglês

10.1093/jn/107.3.458

1541-6100

B. Hannett, David W. Thomas, A H Chalmers, A M Rofe, J.B. Edwards, R. G. Edwards,

Metabolism and Genetic Disorders

Glucose, fructose, sorbitol and xylitol were assessed as precursors of oxalate in normal rats and rats deficient in thiamin or vitamin B-6. Urinary excretions of oxalate, glyoxylate and glycine were increased significantly in vitamin B-6 deficient rats infused with xylitol when compared with all other groups. Using [U-14C]xylitol, oxalate was shown to be derived directly from this polyalcohol in vitamin B-6 deficient rats. These results suggest that vitamin B-6 deficiency may be a factor contributing to oxalate crystal deposition seen in some patients infused with xylitol.