Effect of oral contraceptive therapy on the renin-angiotensin system in normotensive and hypertensive women.
1973; National Institutes of Health; Volume: 41; Issue: 5 Linguagem: Inglês
Autores
Tapia Hr, Johnson Ce, Strong Cg,
Tópico(s)Reproductive Health and Contraception
ResumoPlasma renin activity, plasma renin substrate (angiotensinogen), angiotensin I (AI), and plasma angiotensinase activity were measured in 8 women who had first become hypertensive during a mean 3.1 years on various oral contraceptives, and in 5 normotensive women, before and after 1 cycle of pills. All were determined by radioimmunoassay. 8 or more blood pressures were taken by 2 observers and averaged. Plasma renin activity increased from mean 2.12 to 3.52 ng/ml/hr (p greater than .2) in normal women, and from 3.0 to 5.06 in hypertensives (p less than .02). The mean plasma renin substrate values for both groups together rose from 1881 ng/ml to 4245 ng/ml. Angiotensin I rose from .029 ng/ml/hr to .049 in normals, and .027 to .037 in hypertensives. Mean plasma angiotensinase activity values rose from 3.6 to 5.4% degraded per minute in normal women and varied only from 6.5 before and to 5.9 after a pill cycle in hypertensive patients. The authors suggest that development of hypertension during oral contraceptive therapy may be due to abnormal inactivation of angiotensin.
Referência(s)