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Breakable mesoporous silica nanoparticles for targeted drug delivery

2016; Royal Society of Chemistry; Volume: 8; Issue: 13 Linguagem: Inglês

10.1039/c5nr09112h

2040-3372

Laura Maggini, Ingrid Cabrera, Amparo Ruiz‐Carretero, Eko Adi Prasetyanto, Éric Robinet, Luisa De Cola,

Advanced Nanomaterials in Catalysis

"Pop goes the particle". Here we report on the preparation of redox responsive mesoporous organo-silica nanoparticles containing disulfide (S–S) bridges (ss-NPs) that, even upon the exohedral grafting of targeting ligands, retained their ability to undergo structural degradation, and increase their local release activity when exposed to a reducing agent. This degradation could be observed also inside glioma C6 cancer cells. Moreover, when anticancer drug-loaded pristine and derivatized ss-NPs were fed to glioma C6 cells, the responsive hybrids were more effective in their cytotoxic action compared to non-breakable particles. The possibility of tailoring the surface functionalization of this hybrid, yet preserving its self-destructive behavior and enhanced drug delivery properties, paves the way for the development of effective biodegradable materials for in vivo targeted drug delivery.