Conjugated Hemoglobin: Rightshifted Dextran-Hemoglobin as Blood Substitute
1988; Marcel Dekker; Volume: 16; Issue: 1-3 Linguagem: Inglês
10.3109/10731198809132573
ISSN0890-5533
Autores Tópico(s)Erythrocyte Function and Pathophysiology
ResumoCovalent modification of hemoglobin and dextran-hemoglobin by reductive alkylation under aerobic conditions with periodated inositol tetrakisphosphate brought about a rightshifting of their oxygen dissociation curves. The rightshifted dextran-hemoglobin conjugate provided adequate oxygen delivery in macaques exchange-transfused to 90% with respect to their erythrocyte content. The conjugate did not exhibit the nephrotoxicity of free hemoglobin. It was also more resistant to precipitation, and therefore more amenable to viral sterilisation, by ethanol.
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