Peripheral nervous system involvement in primary burning mouth syndrome—results of a pilot study
2016; Wiley; Volume: 22; Issue: 4 Linguagem: Inglês
10.1111/odi.12454
ISSN1601-0825
AutoresAntti Puhakka, Heli Forssell, Seppo Soinila, A. Virtanen, Matias Röyttä, Merja Laine, Olli Tenovuo, Tuija Teerijoki‐Oksa, S. Jääskeläinen,
Tópico(s)Botulinum Toxin and Related Neurological Disorders
ResumoObjective The pathophysiology of primary burning mouth syndrome ( BMS ) has remained enigmatic, but recent studies suggest pathology within the nervous system at multiple levels. This study aimed to investigate in detail the contribution of either focal or generalized alterations within the peripheral nervous system ( PNS ) in the etiopathogenesis of BMS . Subjects and methods Intraepithelial nerve fiber density ( IENFD ) of tongue mucosa was assessed in 10 carefully characterized BMS , and the results were compared to 19 age‐ and gender‐matched cadaver controls, 6 with lifetime diabetes. Extensive neurophysiologic and psychophysical examinations of the trigeminal system and distal extremities were performed to profile PNS function in BMS . Results Patients with BMS had significantly fewer intraepithelial nerve fibers (0,27, s.e. 0,18 mm −1 ; P = 0.0253) than non‐diabetic controls (0,92, s.e. 0,15 mm −1 ). In the subepithelial space, the amount of nerve fibers did not differ between the groups. The majority (9/10) of patients with BMS showed neurophysiologic or psychophysical signs of a more generalized PNS dysfunction. Conclusions Our results in neurophysiologically optimally characterized BMS patients confirm that pure focal small fiber neuropathy of the oral mucosa has a role in the pathophysiology of primary BMS . Furthermore, BMS may be related to a more generalized, yet subclinical peripheral neuropathy.
Referência(s)