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Metabolic Heterogeneity in Human Lung Tumors

2016; Cell Press; Volume: 164; Issue: 4 Linguagem: Inglês

10.1016/j.cell.2015.12.034

1097-4172

Christopher T. Hensley, Brandon Faubert, Qing Yuan, Naama Lev‐Cohain, Eunsook S. Jin, Jiyeon Kim, Lei Jiang, Bookyung Ko, Rachael Skelton, Laurin Loudat, Michelle Wodzak, Claire Klimko, Elizabeth A. McMillan, Yasmeen M. Butt, Min Ni, Dwight Oliver, José Torrealba, Craig R. Malloy, Kemp H. Kernstine, Robert E. Lenkinski, Ralph J. DeBerardinis,

RNA modifications and cancer

Non-small cell lung cancer (NSCLC) is heterogeneous in the genetic and environmental parameters that influence cell metabolism in culture. Here, we assessed the impact of these factors on human NSCLC metabolism in vivo using intraoperative 13C-glucose infusions in nine NSCLC patients to compare metabolism between tumors and benign lung. While enhanced glycolysis and glucose oxidation were common among these tumors, we observed evidence for oxidation of multiple nutrients in each of them, including lactate as a potential carbon source. Moreover, metabolically heterogeneous regions were identified within and between tumors, and surprisingly, our data suggested potential contributions of non-glucose nutrients in well-perfused tumor areas. Our findings not only demonstrate the heterogeneity in tumor metabolism in vivo but also highlight the strong influence of the microenvironment on this feature.