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Infection and dissemination of two dengue type-2 viruses isolated from patients exhibiting different disease severity in orally infected Aedes aegypti from different geographic origin

2002; Japan Society of Medical Entomology and Zoology; Volume: 53; Issue: 1 Linguagem: Inglês

10.7601/mez.53.21

2185-5609

Ronald Enrique Morales Vargas, Kouichi Morita, Yuki Eshita, Yoshio Tsuda, Toshihide Fukuma, Masahiro Takagi,

Dengue and Mosquito Control Research

The capacity for oral infection and dissemination of two dengue type-2 viruses, ThNH7/93 and ThNHpll/93, isolated from patients exhibiting different disease severity, dengue shock syndrome (DSS) and classical dengue fever (DF), respectively, was compared in two strains of Aedes aegypti from different geographic origin. The capacity for oral infection and dissemination to the head tissues of the isolate ThNH7/93 (DSS) was significantly higher in the Ae. aegypti strain from Nakhon Phanom, Thailand, than that in the strain from Escuintla, Guatemala, (P 0.05, x^2=0.557, df= 1). The Ae. aegypti strain from the location where the viruses were isolated (Nakhon Phanom, Thailand) showed significantly higher susceptibility to the isolate ThNH7/93 strain than to the isolate ThNHpll/93 (P 0.05, x^2=0.049, df= 1). These results suggested that the efficacy of dengue virus circulation was likely to vary according to combination of the virus strains and origin of the vector mosquitoes.