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Peripheral Plasma Vitamin D and Non-HDL Cholesterol Reflect the Severity of Cerebral Cavernous Malformation Disease

2016; Future Medicine; Volume: 10; Issue: 3 Linguagem: Inglês

10.2217/bmm.15.118

1752-0371

Romuald Girard, Omaditya Khanna, Robert Shenkar, Lingjiao Zhang, Meijing Wu, Michael Jesselson, Hussein A. Zeineddine, Anupriya Gangal, Maged D Fam, Christopher C. Gibson, Kevin J. Whitehead, Dean Y. Li, James K. Liao, Changbin Shi, Issam A. Awad,

Cerebrospinal fluid and hydrocephalus

Aim: To correlate cerebral cavernous malformations (CCMs) disease aggressiveness with peripheral blood biomarkers hypothesized mechanistically. Patients & methods: A prospective case–control study enrolled 43 CCM patients, where 25-(OH) vitamin D, HDL and non-HDL cholesterol, CRP plasma levels and leukocyte ROCK activity were correlated with parameters of disease aggressiveness reflecting chronic and acute domains. Results: Patients with one or more features of chronically aggressive disease (early age at symptom onset, two or more symptomatic bleeds, high lesion burden) had significantly lower 25-(OH) vitamin D and non-HDL cholesterol levels in comparison to patients without these features. Conclusion: Validation of these biomarkers and their potential treatment modulation may influence the clinical care of patients with CCM disease.