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Cellular and molecular mechanisms underlying axon formation, growth, and branching

2013; Rockefeller University Press; Volume: 202; Issue: 6 Linguagem: Inglês

10.1083/jcb.201305098

1540-8140

Tommy L. Lewis, Julien Courchet, Franck Polleux,

Developmental Biology and Gene Regulation

Proper brain wiring during development is pivotal for adult brain function. Neurons display a high degree of polarization both morphologically and functionally, and this polarization requires the segregation of mRNA, proteins, and lipids into the axonal or somatodendritic domains. Recent discoveries have provided insight into many aspects of the cell biology of axonal development including axon specification during neuronal polarization, axon growth, and terminal axon branching during synaptogenesis.