Artigo Acesso aberto Revisado por pares

Ly-6A is required for T cell receptor expression and protein tyrosine kinase fyn activity.

1994; Springer Nature; Volume: 13; Issue: 9 Linguagem: Inglês

10.1002/j.1460-2075.1994.tb06493.x

ISSN

1460-2075

Autores

Sang‐Kyou Lee, Bing Su, Stephen E. Maher, Alfred L.M. Bothwell,

Tópico(s)

Galectins and Cancer Biology

Resumo

Research Article1 May 1994free access Ly-6A is required for T cell receptor expression and protein tyrosine kinase fyn activity. S.K. Lee S.K. Lee Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520-8011. Search for more papers by this author B. Su B. Su Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520-8011. Search for more papers by this author S.E. Maher S.E. Maher Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520-8011. Search for more papers by this author A.L. Bothwell A.L. Bothwell Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520-8011. Search for more papers by this author S.K. Lee S.K. Lee Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520-8011. Search for more papers by this author B. Su B. Su Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520-8011. Search for more papers by this author S.E. Maher S.E. Maher Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520-8011. Search for more papers by this author A.L. Bothwell A.L. Bothwell Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520-8011. Search for more papers by this author Author Information S.K. Lee1, B. Su1, S.E. Maher1 and A.L. Bothwell1 1Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520-8011. The EMBO Journal (1994)13:2167-2176https://doi.org/10.1002/j.1460-2075.1994.tb06493.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info To characterize the function of the Ly-6A antigen in T cell activation, antisense Ly-6 RNA was expressed in a stably transfected antigen-specific T cell clone. Reduced Ly-6A expression results in inhibition of responses to antigen, anti-TCR (anti-T cell receptor) crosslinking and concanavalin A plus recombinant interleukin 1 and causes impairment of in vitro fyn tyrosine kinase activity. More substantial reduction of Ly-6A results in reduction of TCR expression. Analysis of mRNA species indicates that the reduction is specific for the TCR beta chain. These data demonstrate that Ly-6A may regulate TCR expression and may be involved in early events of T cell activation via regulation of fyn tyrosine kinase activity. Previous ArticleNext Article Volume 13Issue 91 May 1994In this issue RelatedDetailsLoading ...

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