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p38γ and p38δ reprogram liver metabolism by modulating neutrophil infiltration

2016; Springer Nature; Volume: 35; Issue: 5 Linguagem: Inglês

10.15252/embj.201591857

1460-2075

Bárbara González‐Terán, Nuria Matesanz, Ivana Nikolić, María Angeles Verdugo, Vinatha Sreeramkumar, Lourdes Hernández‐Cosido, Alfonso Mora, Georgiana Crainiciuc, María Laura Sáiz, Edgar Bernardo, Luis Leiva‐Vega, Elena M. Rodríguez Rodríguez, Víctor Bondía, Jorge Torres, Sonia Perez‐Sieira, Luís Ortega, Ana Cuenda, Francisco Sánchez‐Madrid, Rubén Nogueiras, Andrés Hidalgo, Miguel Marcos, Guadalupe Sabio,

Hepatitis C virus research

Abstract Non‐alcoholic fatty liver disease ( NAFLD ) is a major health problem and the main cause of liver disease in Western countries. Although NAFLD is strongly associated with obesity and insulin resistance, its pathogenesis remains poorly understood. The disease begins with an excessive accumulation of triglycerides in the liver, which stimulates an inflammatory response. Alternative p38 mitogen‐activated kinases (p38γ and p38δ) have been shown to contribute to inflammation in different diseases. Here we demonstrate that p38δ is elevated in livers of obese patients with NAFLD and that mice lacking p38γ/δ in myeloid cells are resistant to diet‐induced fatty liver, hepatic triglyceride accumulation and glucose intolerance. This protective effect is due to defective migration of p38γ/δ‐deficient neutrophils to the damaged liver. We further show that neutrophil infiltration in wild‐type mice contributes to steatosis development by means of inflammation and liver metabolic changes. Therefore, p38γ and p38δ in myeloid cells provide a potential target for NAFLD therapy.