Development of a Soft Physicochemical Stomach (SPS) Model for Simulation of the Human Gastric Digestion and Examining of the Ph Profile
2008; Linguagem: Inglês
Autores
Michelle Ji Yeon Yoo, XDong Chen,
Tópico(s)Diet and metabolism studies
ResumoThe ongoing demand of health promotion, indulgence and convenience of food consumption has led to a massive scale of production of processed foods. For health purposes, functional foods are designed and they need to be examined for their usefulness and how they may be consumed by human. A soft physicochemical stomach (SPS) model which mimics the physiological conditions of the human stomach has been built for the first time to examine the digestive behaviour of food products. The experiments on rice samples were conducted at 37 1{degree}C inside an anaerobic incubator. The new stomach system has key features including realistic geometry and anatomy, physiological transit time, appropriate compositions and controlled rates of the secretions, hormonal feed-back control, presence of mucosal lining, appropriate ingestion method, buffering capacity of the food and practical simulation of 'peristaltic motility'. Samples collected from the SPS model were analysed using pH meter and showed a good buffering effect of the ingested meal and re-establishment of the fasting pH after 3hrs of digestion. These results correspond well with the pH ranges that were collected from healthy volunteers in the literature showing a promise of the current approach. The SPS model and its improved versions may well be used as a screening tool prior to marketing in functional food development area or clinical trials. It is economic, efficient in time and labour, has good reproducibility and very importantly, it does not violate ethical constraints.
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