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High Streptococcus pneumoniae colonization prevalence among HIV-infected Kenyan parents in the year before pneumococcal conjugate vaccine introduction

2015; BioMed Central; Volume: 16; Issue: 1 Linguagem: Inglês

10.1186/s12879-015-1312-2

1471-2334

Laura Conklin, Godfrey Bigogo, Geofrey Jagero, Lee M. Hampton, Muthoni Junghae, María da Gloria Carvalho, Fabiana Cristina Pimenta, Bernard Beall, Thomas H. Taylor, Brian D. Plikaytis, Kayla F. Laserson, John Vulule, Chris Van Beneden, Cynthia G. Whitney, Robert F. Breiman, Daniel R. Feikin,

Respiratory viral infections research

Streptococcus pneumoniae is a leading cause of pneumonia, meningitis and sepsis in developing countries, particularly among children and HIV-infected persons. Pneumococcal oropharyngeal (OP) or nasopharyngeal (NP) colonization is a precursor to development of invasive disease. New conjugate vaccines hold promise for reducing colonization and disease. Prior to introduction of 10-valent pneumococcal conjugate vaccine (PCV10), we conducted a cross-sectional survey among HIV-infected parents of children 250 were protective (OR = 0.6; 95 % CI 0.4, 0.9 and OR = 0.5; 95 % CI 0.2, 0.9, respectively); other associations were not identified. Among 309 isolates tested from all parents, 255 (80.4 %) were penicillin non-susceptible (MIC ≥0.12 μg/ml). Prevalence of pneumococcal colonization is high among HIV-infected parents in rural Kenya. If young children are the pneumococcal reservoir for this population, PCV10 introduction may reduce vaccine-type colonization and disease among HIV-infected parents through indirect protection.