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Cerebrospinal fluid amounts of HLA-G in dimeric form are strongly associated to patients with MRI inactive multiple sclerosis

2015; SAGE Publishing; Volume: 22; Issue: 2 Linguagem: Inglês

10.1177/1352458515590647

1477-0970

Enrico Fainardi, Daria Bortolotti, Silvia Bolzani, Massimiliano Castellazzi, Carmine Tamborino, Gloria Roversi, Eleonora Baldi, Maria Luisa Caniatti, Ilaria Casetta, Valentina Gentili, Enrico Granieri, Roberta Rizzo, Enrico Granieri, Massimiliano Castellazzi, Ilaria Casetta, MR Tola, Enrico Fainardi, Franco Dallocchio, Tiziana Bellini, Roberta Rizzo, Antonella Rotola, Dario Di Luca, Silva Seraceni, Carlo Contini, Silvia Sabbioni, Massimo Negrini, Mauro Tognon, Tiziana Antonelli, Elisabetta Groppo, Mauro Gentile, Eleonora Baldi, M. L. Caniatti, Stefano Ceruti, Maria Cristina Manfrinato, Alessandro Trentini, Daria Bortolotti, Eliane Correa Miotto, Manuela Ferracin, Elisa Mazzoni, Silvia Pietrobon, Irene Masini, John Charles Rotondo, Fernanda Martini, Antônio Cláudio do Amaral Baruzzi, Raffaella D‘Alessandro, Roberto Michelucci, Fabrizio Salvi, S. Stecchi, C. Scandellari, Giovanni Terzano, Franco Granella, Paolo Nichelli, P. Sola, Diana Ferraro, Francesca Vitetta, AM Simone, Roberta Bedin, Norina Marcello, L. Motti, Sara Montepietra, Donata Guidetti, Paolo Immovilli, E. Montanari, Ilaria Pesci, A Guareschi, Grazia Greco, Michele Santangelo, Mauro Am, Susanna Malagù, F Rasi, M. A. Spadoni, M. Galeotti, L. Fiorani, W. Neri, Alessandro Ravasio, Marco Pasquinelli, Steven Gutman, Chiara Monaldini,

Elbow and Forearm Trauma Treatment

The relevance of human leukocyte antigen (HLA)-G in dimeric form in multiple sclerosis (MS) is still unknown.To investigate the contribution of cerebrospinal fluid (CSF) HLA-G dimers in MS pathogenesis.CSF amounts of 78-kDa HLA-G dimers were measured by western blot analysis in 80 MS relapsing-remitting MS (RRMS) patients and in 81 inflammatory and 70 non-inflammatory controls.CSF amounts of 78 kDa HLA-G dimers were more frequent in RRMS than in inflammatory (p<0.01) and non-inflammatory controls (p<0.001) and in magnetic resonance imaging (MRI) inactive than in MRI active RRMS (p<0.00001).Our findings suggest that HLA-G dimers may be implicated in termination of inflammatory response occurring in MS.