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Dracula was right: The elixir of youth could be the young blood

2015; Elsevier BV; Volume: 90; Issue: 9 Linguagem: Inglês

10.1016/j.oftale.2015.10.004

2173-5794

V.M. Asensio-Sánchez,

Natural product bioactivities and synthesis

Two new diterpenoids trivially named Stachysrosane (1) and Stachysrosane (2) have been isolated from the ethyl acetate soluble fraction of Stachys parviflora. The structure elucidation of isolated diterpenoids were based on one-(1D) and two-dimensional (2D)-NMR techniques including correlation spectroscopy (COSY), heteronuclear multiple quantum coherence (HMQC), heteronuclear multiple bond correlation (HMBC), and nuclear Overhauser effect spectroscopy (NOESY). The isolated diterpenoids 1 and 2 caused marked attenuation of castor oil induced diarrhea in dose dependent manner with 100% and 70% protection at 45 mg/kg p.o. respectively. It can be concluded with confidence that both the isolated compounds could be useful antidiarrheal agents; however, detailed studies will be needed.