Effect of IgG produced by tumor-infiltrating B lymphocytes on lung tumor growth.
2006; International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts; Volume: 26; Linguagem: Inglês
ISSN
1791-7530
AutoresMakiko Mizukami, Takeshi Hanagiri, Yoshiki Shigematsu, Tetsuro Baba, Takashi Fukuyama, Yoshika Nagata, Tetsuya So, Yoshinobu Ichiki, Masakazu Sugaya, Manabu Yasuda, Tomoko So, Mitsuhiro Takenoyama, Kenji Sugio, Kosei Yasumoto,
Tópico(s)Glycosylation and Glycoproteins Research
ResumoBackground: Tumor-infiltrating B lymphocytes (TIB) are often observed in lung cancer. The role of TIB in tumor growth has not been well investigated. Materials and Methods: Forty-four surgically-resected human lung cancer tissues were xenotransplanted into SCID mice. Their blood was collected and the volume of the transplanted tumors was measured regularly. The correlations between the IgG titer in the sera and the growth of the transplanted tumors according to the clinicopathological variables were examined. Results: Human IgG production from TIB was observed in the all xenotransplanted mice. Twenty-seven out of the 44 tumors regressed gradually. The average serum human IgG level of the tumor regressors (n=10) was significantly higher than that of the progressors (n=9) in squamous cell carcinoma (p=0.02), while there was no significant difference in the other histological groups. Conclusion: IgG produced by TIB might play a crucial role in preventing tumor growth in squamous cell carcinoma. It is well accepted that tumor-infiltrating T lymphocytes (TIL) and tumor-associated macrophages (TAM) regulate the tumor-host relationship in various tumors (1). The functions of TIL have been well investigated (2). TIL recognize tumor- associated antigens and numerous tumor antigens have been
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